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Division of Communicable Disease Control

Monkeypox (MPX)

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Vaccination helps to protect against monkeypox when given before or shortly after an exposure. There are two monkeypox vaccines currently available in the United States via the Strategic National Stockpile.  

At this time, the federal government has allocated a limited number of JYNNEOS vaccine doses to Californians. The California Department of Public Health is working with the Centers for Disease Control and Local Health Departments to make these doses available to protect against monkeypox. JYNNEOS is licensed for adults 18 years and over. It is administered as a two dose injection series in the upper arm at least four weeks apart. Most people who receive the JYNNEOS vaccine have only minor reactions such as pain, redness, swelling and itching at the injection site. Less commonly, people also may experience muscle pain, headache, fatigue (tiredness), nausea, chills, and fever.

The  CDC advises  that  people who have been exposed to monkeypox be given the vaccine to prevent them from developing the disease. This is called post-exposure prophylaxis or PEP. PEP is most effective at preventing monkeypox if the vaccine is administered  within 4 days of exposure. If given between 4–14 days after the date of exposure, vaccination may help reduce symptoms, but may not prevent the infection from developing.

 At this time, the JYNNEOS vaccine is being prioritized for the following groups:

  • Post-Exposure Prophylaxis (PEP) for known close contacts of monkeypox cases who are identified by public health via case investigation, contact tracing, and risk exposure assessments.

  • Post-Exposure Prophylaxis (PEP)++  for individuals with certain risk factors who are more likely to have been recently exposed to monkeypox even if they have not had documented exposure to someone with confirmed monkeypox, such as people who attended an event or venue where there was known monkeypox exposure.

  • Pre-Exposure Prophylaxis (PrEP) for individuals at occupational risk of monkeypox according to Advisory Committee on Immunization Practices (ACIP) guidance, including: laboratory workers who perform monkeypox testing, and clinical and public health workers who collect monkeypox specimens.

On July 19, California sent a letter to the Centers for Disease Control and Prevention outlining a request for additional doses of vaccine. Additional doses will eventually allow for expansion of vaccination efforts to include PrEP to other individuals, including gay, bisexual, trans and other men who have sex with men who are at high risk of monkeypox exposure.

Stay up to date on the latest information regarding vaccine strategies for monkeypox. 


Vaccine Resources for the General Public:

Vaccine Resources for Healthcare Providers:

Vaccine Resources for Local Health Departments:

Monkeypox Allocation at Local Health Jurisdictions 

Allocation numbers are updated on Thursdays. 

Table 1. Vials Allocated by CDPH and Los Angeles County 

  Phase 0 Phase 1 Phase 2a Phase 2b Phase 3a Phase 3bc Phase 4a Total
1060 6346 9812 6824 19240 5780 8260 57322
CA/CDPH 2540 9556 14774 10299 29020 8720 12440 87349
Total 3600 15902 24586 17123 48260 14500 20700 144671
Note:  Doses for Los Angeles County are allocated separately by CDC

Table 2. Number of Jynneos vaccine vials distributed to Local Health Jurisdictions in Phases 0, 1, 2a, 2b, 3a, and 3bc as of 8/25/2022

Local Health Jurisdiction
Vials Distributed*
Alameda 5,980
Alpine 0
Amador 0
Berkeley 1,183
Butte 50
Calaveras 20
Colusa 0
Contra Costa 3,062
Del Norte 0
El Dorado 30
Fresno 800
Glenn 0
Humboldt 146
Imperial 140
Inyo 0
Kern 944
Kings 20
Lake 10
Lassen 0
Los Angeles** 57,322
Madera 25
Marin 504
Mariposa 2
Mendocino 36
Merced 40
Modoc 0
Mono 5
Monterey 498
Napa 170
Nevada 50
Orange 3,372
Placer 201
Plumas 0
Riverside 6,074
Sacramento 5,908
San Benito 20
San Bernardino 1,328
San Diego 6,059
San Francisco 24,318
San Joaquin 822
San Luis Obispo 90
San Mateo 1,476
Santa Barbara 445
Santa Clara 5,304
Santa Cruz 714
Shasta 47
Sierra 0
Siskiyou 0
Solano 817
Sonoma 1,190
Stanislaus 282
Sutter 20
Tehama 0
Trinity 0
Tulare 206
Tuolumne 0
Ventura 464
Yolo 60
Yuba 20
TOTAL 130,274
RESERVE† 1,957

* Distributed vials have been sent or received by the respective jurisdiction
** Pasadena and Long Beach included in Los Angeles distribution.
† CDPH remaining reserve vials not yet distributed.​​

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