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healthcare-associated infections (haI) program

Regional Prevention Collaboratives

Antimicrobial resistance (AR), including Clostridioides difficile infection (CDI), is a growing threat to public health and can spread across the healthcare continuum when patients move between facilities. Healthcare facilities can address AR in their region by working in conjunction with local public health and other facilities in their local healthcare network. The CDPH Healthcare-Associated Infections (HAI) Program works with healthcare facilities and local health departments (LHD) to convene regionally-based projects to improve AR prevention measures across the continuum of care.

What is a

​Regional AR prevention collaboratives are partnerships between LHD and networks of healthcare facilities (including hospitals, long-term acute care hospitals, skilled nursing facilities, and outpatient clinics) with a shared patient population. Collaborative participants work together to implement AR prevention best practices both within individual facilities and during transitions of care. Regional AR prevention collaboratives provide opportunities for healthcare facilities and LHD to build relationships, coordinate and share best practices in an in-person and interactive setting. When developing a regional collaborative, we consider the needs, interests, and resources of each region to align project goals and to ensure program sustainability.

​Project List

​The HAI Program has convened regional AR prevention collaboratives since 2015. Regions were selected based on high incidence of AR/CDI or risk for emergence of AR.

Emergency  Department Antibiotic Resistance Prevention Collaborative (Statewide)

Imperial County Antibiotic Stewardship Collaborative*

Long Beach CRE Prevention Collaborative*

Orange County CDI Prevention Collaborative*

Riverside County / Desert Health Care District CDI Prevention Collaborative*

Sacramento Metropolitan Area CDI Prevention Collaborative*

San Francisco Bay Area CRE Prevention Collaborative*


*Completed project.

​Implement a Collaborative 
Project in
Your Region
or Network

​Individuals and organizations (for example, healthcare systems or LHD) interested in convening AR prevention projects may choose to convene a collaborative that focuses on condition-specific topics (for example, reducing CDI  or carbapenem-resistant Enterobacteriaceae (CRE)) or topics that are more broadly focused (for example, antimicrobial stewardship ). We encourage organizations to choose topics that are relevant to their region and their patient population. Collaborative participants may decide to meet on a regular (for example, quarterly) basis to develop and strengthen relationships, foster communication, and participate in training and education sessions.

Collaborative Toolkit

The HAI Program is developing a toolkit to help guide and plan regional collaboratives in your area; the toolkit may be used to help guide project plan development. An draft copy is available upon request.

The following tools are available for use in a collaborative. The HAI Program may have additional educational material available for use and can offer content expertise upon request. Contact the HAI Program at

Infection Control Assessments

Antimicrobial Stewardship

  • Antibiotic Use Information

Interfacility Transfer Communication

Communicating AR/CDI status ahead of time when transferring a patient/resident helps ensure appropriate infection prevention measures are maintained at the receiving facility. A template CDPH Interfacility Infection Control Transfer Form  is available via the Interfacility Transfer Communications Guide page

​Contact Us

​The HAI Program provides consultative support to coordinate regional prevention collaboratives. Contact us at


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